Protein Details: Neuronal acetylcholine receptor subunit beta-4

Protein ID

ICDB_Pro_0476

Protein Name

Neuronal acetylcholine receptor subunit beta-4

Gene Name

CHRNB4

Organism

Homo sapiens (Human)

Length

498 amino acids

AlphaFoldDB

AF-P30926-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD

PDB Structures

6PV7 6PV8

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Tobacco Addiction and Primary Thrombocytopenia

Location

DOI ID

10.1016/s0021-9258(18)38201-2

RefSeq

NP_989746.1